This first volume of 49 CFR contains all of Subtitle A (Parts 1-99) and contains regulations relating to the Office of the Secretary of Transportation:

• Part 1: Organization and Delegation of Powers and Duties
• Part 3: Official Seal
• Part 5: Rulemaking Procedures
• Part 6: Implementation of Equal Access to Justice Act in Agency Proceedings
• Part 7: Public Availability of Information
• Part 8: Classified Information—Classification/Declassification/Access
• Part 9: Testimony of Employees of the Department and Production of Records in Legal Proceedings
• Part 10: Maintenance of and Access to Records Pertaining to Individuals
• Part 11: Protection of Human Subjects
• Part 15: Protection of Sensitive Security Information
• Part 17: Intergovernmental Review of Department of Transportation Programs and Activities
• Part 18: Uniform Administrative Requirements for Grants and Cooperative Agreements to State and Local Governments
• Part 19: Uniform Administrative Requirements for Grants and Agreements With Institutions of Higher Education, Hospitals, and Other Non-Profit Organizations
• Part 20: New Restrictions on Lobbying
• Part 21: Nondiscrimination in Federally-Assisted Programs of the Department of Transportation—Effectuation of Title VI of the Civil Rights Act of 1964
• Part 22: Short-Term Lending Program (STLP)
• Part 23: Participation of Disadvantaged Business Enterprise in Airport Concessions
• Part 24: Uniform Relocation Assistance and Real Property Acquisition for Federal and Federally-Assisted Programs
• Part 25: Nondiscrimination on the Basis of Sex in Education Programs or Activities Receiving Federal Financial Assistance
• Part 26: Participation by Disadvantaged Business Enterprises in Department of Transportation Financial Assistance Programs
• Part 27: Nondiscrimination on the Basis of Disability in Programs or Activities Receiving Federal Financial Assistance
• Part 28: Enforcement of Nondiscrimination on the Basis of Handicap in Programs or Activities Conducted by the Department of Transportation
• Part 30: Denial of Public Works Contracts to Suppliers of Goods and Services of Countries That Deny Procurement Market Access to US Contractors
• Part 31: Program Fraud Civil Remedies
• Part 32: Governmentwide Requirements for Drug-Free Workplace (Financial Assistance)
• Part 33: Transportation Priorities and Allocation System
• Part 37: Transportation Services for Individuals With Disabilities (ADA)
• Part 38: Americans With Disabilities Act (ADA) Accessibility Specifications for Transportation Vehicles
• Part 39: Transportation for Individuals With Disabilities—Passenger Vessels
• Part 40: Procedures for Transportation Workplace Drug and Alcohol Testing Programs
• Part 41: Seismic Safety
• Part 71: Standard Time Zone Boundaries
• Part 79: Medals of Honor
• Part 80: Credit Assistance for Surface Transportation Projects
• Part 89: Implementation of the Federal Claims Collection Act
• Part 91: International Air Transportation Fair Competitive Practices
• Part 92: Recovering Debts to the United States by Salary Offset
• Part 93: Aircraft Allocation
• Part 95: Advisory Committees
• Part 98: Enforcement of Restrictions on Post-Employment Activities
• Part 99: Employee Responsibilities and Conduct

Title 49 of the US Code of Federal Regulations (49 CFR) contains all US regulations dealing with Transportation in the United States. The Title is organized into nine volumes, and the regulations it contains are authored by various components of the Departments of Transportation and Homeland Security. Most notably, 49 CFR contains the US Hazardous Material Regulations (HMR) in Chapter I.